LLFS News and Media



Families with long, healthy life spans focus of $68 million grant

Long life study explores genetics of extreme longevity.
December 5, 2019


In reference to: Fagan, E, Sun, F, Bae, H, Elo, I, Andersen, S, Lee, J, Christensen, K, Thyagarajan, B, Sebastiani, P, Perls, T, Honig, L, Schupf, N. Telomere length is longer in women with late maternal age. Menopause: May 2017, 24 (5) 497-50. PMID: 27922939 PMCID: PMC5403597.  [Note that this paper was published in the last reporting period, however the following media reports were published after June, 2017]

In reference to: Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P.  Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies, The Journals of Gerontology: Series A, , 2017 Oct; 72(11): 1453–1464 glx124, https://doi.org/10.1093/gerona/glx124  PMC5861867

  •  Genetic influence on aging into the 90s but not beyond — ScienceDaily  https://www.sciencedaily.com/releases/2017/07/170718142903.htm  Jul 18, 2017 – Effects of FOXO3 polymorphisms on survival to extreme longevity in four centenarian studies. The Journals of Gerontology: Series A, 2017; DOI: …
  •  Association of the FOXO3A Locus with Extreme Longevity in a …  https://www.liebertpub.com/doi/10.1089/rej.2008.0827  We validated the association of FOXO3A polymorphisms with extreme longevity in males from the Southern Italian Centenarian Study. Particularly, rs2802288, a …
  • New findings suggest a genetic influence on aging into the 90s but not …  https://medicalxpress.com/news/2017-07-genetic-aging-90s.html  Jul 18, 2017 – … The Longevity Genes Project at Albert Einstein College of Medicine; and the National Institutes on Aging-funded Long Life Family Study.
  • New findings suggest a genetic influence on aging into the 90s but not …  https://www.eurekalert.org/pub_releases/2017-07/osu-nfs071817.php  July 18, 2017. CORVALLIS, Ore. – Variants of a gene thought to be linked to longevity appear to influence aging into the 90s, but do not appear to affect exceptional longevity, or aging over 100, a new study has found.

In reference to the Long Life Family Study, generally:



In reference to: Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, Christensen K, Thyagarajan B, Sebastiani P, Perls T, Honig LS, Schupf N. Telomere length is longer in women with late maternal age. Menopause (New York, NY). 2016. Epub 2016/12/07. doi: 10.1097/gme.0000000000000795. PubMed PMID: 27922939.

In reference to the Long Life Family Study, generally:

In reference to: Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT. Biomarker signatures of aging. Aging Cell 2017.  pp1-10.  Doi: 10.111/acel.12557.PMID: 28058805. PMCID: PMC5334528

In reference to: Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy Andersen, Alberto Malovini, Gil Atzmon, Francesco Villa, Aldi T. Kraja, Danny Ben-Avraham, Nir Barzilai, Annibale Puca, Thomas T. Perls. Four Genome-Wide Association Studies Identify New Extreme Longevity VariantsThe Journals of Gerontology: Series A, 2017; DOI: 10.1093/gerona/glx027

  • New genetic variants associated with extreme old age
    April 27, 2017 – New genetic variants associated with extreme old age. The search for the genetic determinants of extreme longevity has been challenging, with the prevalence of centenarians (people older than 100) just one per 5,000 population in developed nations. But a recently published study that combines four studies of extreme longevity, has identified new rare variants in chromosomes 4 and 7 associated with extreme survival and with reduced risks for cardiovascular and Alzheimer’s disease.

In reference to: Pedersen JK, Elo ITSchupf NPerls TTStallard EYashin AIChristensen K. The Survival of Spouses Marrying Into Longevity-Enriched Families. J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):109-114. Epub 2016 Aug 18.


Prior to 2016

Women having babies later in life more likely to live longer | EurekAlert! Science News  Public Release: 25-Jun-2014 Women having babies later in life more likely to live longer.  Nested, case-control study confirms association between older maternal age at birth of last child and exceptional longevity. The North American Menopause Society (NAMS).

Study examines cognitive impairment in families with exceptional longevity | EurekAlert! Science News  Public Release: 6-MAY-2013 A study by Stephanie Cosentino, Ph.D., of Columbia University, New York, and colleagues examines the relationship between families with exceptional longevity and cognitive impairment consistent with Alzheimer’s disease.

Chromosomal Location of Exceptional Memory Identified. MedicalResaerch.com Interview with: Sandra Barral Rodriguez, Ph.D. (Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly. Barral S, et al. JAMA Neurol 2014;71:1514-1519). https://medicalresearch.com/genetic-research/chromosomal_location_of_exceptional_memory_identified/9560/?print=pdf

Those with more lifespan also have more healthspan. Researchers compared the health-spans of older generation subjects of the Long Life Family Study (LLFS) to controls without family history of longevity and to centenarians of the New England Centenarian Study (NECS) using Bayesian parametric survival analysis.

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